Choline Fenofibrate
Names
[ CAS No. ]:
856676-23-8
[ Name ]:
Choline Fenofibrate
[Synonym ]:
Choline fenofibrate
UNII-4BMH7IZT98
fenofibric acid choline salt
ABT-335
Fenofibrate de choline
Biological Activity
[Description]:
Choline Fenofibrate (ABT-335) is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. IC50 value:Target:Several clinical trials have been developed with Choline Fenofibrate on Reverse Cholesterol Transport, Macular Edema and Hypertriglyceridemia.
[Related Catalog]:
[References]
[1]. Jones PH, Bays HE, Davidson MH et al. Evaluation of a new formulation of fenofibric acid, ABT-335, co-administered with statins : study design and rationale of a phase III clinical programme. Clin Drug Investig. 2008;28(10):625-34.
[2]. Mohiuddin SM, Pepine CJ, Kelly MT et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with simvastatin in patients with mixed dyslipidemia: a phase 3, randomized, controlled study. Am Heart J. 2009 Jan;157(1):195-203.
[3]. Zhu T, Awni WM, Hosmane B et al. ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans. J Clin Pharmacol. 2009 Jan;49(1):63-71.
[4]. Goldberg AC, Bays HE, Ballantyne CM et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with atorvastatin in patients with mixed dyslipidemia. Am J Cardiol. 2009 Feb 15;103(4):515-22.
[5]. Campbell J, Mohiuddin SM. The role of a new formulation of fenofibric acid in the treatment of mixed dyslipidemia in type 2 diabetes. Drugs Today (Barc). 2010 Oct;46(10):757-64.
[Related Small Molecules]
Chemical & Physical Properties
[ Boiling Point ]:
486.5ºC at 760 mmHg
[ Molecular Formula ]:
C22H28ClNO5
[ Molecular Weight ]:
421.91400
[ Flash Point ]:
248ºC
[ Exact Mass ]:
421.16600
[ PSA ]:
86.66000
[ LogP ]:
2.16320
[ Storage condition ]:
2-8℃
Synthetic Route
Precursor & DownStream