ST 198

Names

[ Name ]:
ST 198

Biological Activity

[Description]:

ST 198 is an orally active D3R antagonist. ST 198 can block the expression of nicotine-induced CPP at doses selective for D3R. ST 198 can be used for the research of neurological disease[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[In Vitro]

ST 198 可以在对 D3R 具有选择性的剂量下阻断尼古丁诱导的 CPP 的表达[1]。

[In Vivo]

ST 198 (p.o.; 3, 30, 100 mg/kg) 抑制尼古丁 CPPs 的表达[1]。 Animal Model: Rats[1]. Dosage: 3, 30, 100 mg/kg Administration: p.o Result: Displayed nicotine-induced CPP.

[References]

[1]. Le Foll B, et al. Dopamine D3 receptor ligands block nicotine-induced conditioned place preferences through a mechanism that does not involve discriminative-stimulus or antidepressant-like effects. Neuropsychopharmacology. 2005;30(4):720-730.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₆N₂O

[ Molecular Weight ]:
334.45

[ Exact Mass ]:
334.20500

[ PSA ]:
35.83000

[ LogP ]:
4.43270