Thymopoietin II: 32-34

Names

[ Name ]:
Thymopoietin II: 32-34

[Synonym ]:
Rgh 0205
Thymotrinanum [INN-Latin]
Arg-Lys-Asp
Thymotrinanum
N-(N(sup 2)-L-Arginyl-L-lysyl)-L-aspartic acid
Timotrinan
Timotrinan [INN-Spanish]
L-Aspartic acid,N-(N(sup 2)-L-arginyl-L-lysyl)
Thymotrinan
Thymopoietin II: 32-34

Biological Activity

[Description]:

Thymotrinan (RGH-0205) is a biologically active fragment of the naturally occurring thymus hormone thymopoietin and a immunomodulating peptide. Thymotrinan exerts similar immunomodulatory activities to TP5 and to affect humoral as well as cellular responses[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Heizmann J, et al. Enzymatic cleavage of thymopoietin oligopeptides by pancreatic and intestinal brush-border enzymes. Peptides. 1996;17(7):1083-1089.

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Molecular Formula ]:
C₁₆H₃₁N₇O₆

[ Molecular Weight ]:
417.46100

[ Exact Mass ]:
417.23400

[ PSA ]:
246.74000

[ LogP ]:
0.60820

[ Index of Refraction ]:
1.633

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI9099033

CHEMICAL NAME :: L-Aspartic acid, N-(N(sup 2)-L-arginyl-L-lysyl)-

CAS REGISTRY NUMBER :: 85465-82-3

LAST UPDATED :: 199407

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H31-N7-O6

MOLECULAR WEIGHT :: 417.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,764,1986

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,764,1986

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,764,1986

Related Compounds

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