ME-143
Names
[ CAS No. ]:
852536-39-1
[ Name ]:
ME-143
[Synonym ]:
3-(4-hydroxy-phenyl)-2-phenyl-thiazolidin-4-one
3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)chroman-7-ol
4-Thiazolidinone,3-(4-hydroxyphenyl)-2-phenyl
Biological Activity
[Description]:
ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo[1].
[Related Catalog]:
[Target]
NADH oxidase[1]
[In Vitro]
ME-143 (0-100 μM; 48 hours) reduces proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and is more potent than Genistein[1]. Cell Proliferation Assay[1] Cell Line: RKO cell; DLD1 cell Concentration: 0-100 μM Incubation Time: 48 hours Result: Reduced proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and was more potent than Genistein.
[In Vivo]
NADH氧化酶抑制剂
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C21H18O4
[ Molecular Weight ]:
334.36500
[ Exact Mass ]:
334.12100
[ PSA ]:
69.92000
[ LogP ]:
4.11150