KR-32570

Names

[ Name ]:
KR-32570

[Synonym ]:
2-Furancarboxamide, 5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylene)-
5-(5-Chloro-2-methoxyphenyl)-N-(diaminomethylene)-2-furamide
5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylidene)furan-2-carboxamide
KR-32570

Biological Activity

[Description]:

KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM; significantly and concentration dependently improves cardiac contractile function and severe contracture in conjunction with causing a marked reduction in lactate dehydrogenase release at 1-10 uM, possesses potent cardioprotective effects in perfused rat hearts.

[References]

References 1. Lee BH, et al. Eur J Pharmacol. 2005 Mar 28;511(2-3):175-82. 2. Lee S, et al. J Med Chem. 2005 Apr 21;48(8):2882-91. 3. Kim MJ, et al. Eur J Pharmacol. 2005 Nov 21;525(1-3):1-7. 4. Lee KS, et al. Arch Pharm Res. 2006 May;29(5):375-83. View Related Products by Target Sodium Channel

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
474.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₂ClN₃O₃

[ Molecular Weight ]:
293.706

[ Flash Point ]:
240.7±31.5 °C

[ Exact Mass ]:
293.056732

[ LogP ]:
1.28

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.635

Related Compounds

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