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Curculigoside C

Names

[ CAS No. ]:
851713-74-1

[ Name ]:
Curculigoside C

[Synonym ]:
2-(β-D-Glucopyranosyloxy)-5-hydroxybenzyl 3-hydroxy-2,6-dimethoxybenzoate
Benzoic acid, 3-hydroxy-2,6-dimethoxy-, [2-(β-D-glucopyranosyloxy)-5-hydroxyphenyl]methyl ester
Curculigoside C

Biological Activity

[Description]:

Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC50 values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

Curculigoside C 在评估 H2O2[2] 诱导的 SY5Y 细胞死亡中具有神经保护作用。

[In Vivo]

Curculigoside C (15、30 和 60 mg/kg) 表现出快速的口服吸收（Tmax = 0.106 h、0.111 h 和 0.111 h），高消除（t1/2 = 2.022 h、2.061 h 和 2.048 ）和低绝对生物利用度（分别为 2.01%、2.13% 和 2.39%）[2]。 大鼠血浆中 Curculigoside C (CC) 灌胃后的药代动力学参数[1]。

[References]

[1]. Wu Q, et al. Antioxidative phenols and phenolic glycosides from Curculigo orchioides. Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1065-7.  

[2]. Di Wu, et al. Pharmacokinetic and Metabolism Studies of Curculigoside C by UPLC-MS/MS and UPLC-QTOF-MS. Molecules. 2018 Dec 21;24(1):21.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
801.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H26O12

[ Molecular Weight ]:
482.435

[ Flash Point ]:
276.5±27.8 °C

[ Exact Mass ]:
482.142426

[ LogP ]:
-0.63

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.640

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds