CP94253 hydrochloride

Names

[ Name ]:
CP94253 hydrochloride

[Synonym ]:
1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, monohydrochloride
ICI 154,129
CP 94253 hydrochloride

Biological Activity

[Description]:

CP94253 hydrochloride is a potent and selective agonist of 5-HT1B receptor (Ki= 2 nM in a radioligand binding assay).Ki values for 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors are 89, 49, 860, and 1600 nM respectively[1]. CP94253 hydrochloride is centrally active upon systemic administration in vivo[2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Dev.Res. 26 241

[2]. Knobelman DA, Kung HF, Lucki I. Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT(1A) and 5-HT(1B) receptors. J Pharmacol Exp Ther. 2000 Mar;292(3):1111-7

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₀ClN₃O

[ Molecular Weight ]:
293.79200

[ Exact Mass ]:
293.12900

[ PSA ]:
49.94000

[ LogP ]:
3.85920

Related Compounds

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