Flavin adenine dinucleotide disodium salt

Names

[ Name ]:
Flavin adenine dinucleotide disodium salt

[Synonym ]:
Flavaspidic acid
Polystichocitrin
MFCD00151217
5'->5'-ester with adenosine,disodium salt
Toxifren
Glavaspidic acid
Flavaspidsaeure
flavaspidic acid AB
EINECS 282-733-8
Flavaspidic acid BB
flavin-adenin dinucleotide,disodium salt
flaspidic acid-BBBB
flavine-adenine-dinucleotide disodium-salt

Biological Activity

[Description]:

Flavin Adenine Dinucleotide Disodium is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cardiovascular Disease

[In Vitro]

Poly(Flavin Adenine Dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry[2].

[In Vivo]

With flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin Adenine Dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin Adenine Dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin Adenine Dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine[1].

[References]

[1]. Sugiyama S, et al. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Jpn Heart J. 1979 Sep;20(5):657-65.

[2]. Karyakin AA, et al. Electropolymerized flavin adenine dinucleotide as an advanced NADH transducer. Anal Chem. 2004 Apr 1;76(7):2004-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₁N₉Na₂O₁₅P₂

[ Molecular Weight ]:
829.51

[ PSA ]:
397.44000

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
5 g/L

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25-S22

[ WGK Germany ]:
3