Mifamurtide sodium hydrate

Names

[ CAS No. ]:
838853-48-8

[ Name ]:
Mifamurtide sodium hydrate

[Synonym ]:
Mifamurtide
Sodium (5S,10R,13S,16R)-16-{[(3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}-10-carbamoyl-5,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadec-1-yl (2R)-2,3-bis(palmitoyloxy)propyl phosphate hydrate (1:1:1)

Biological Activity

[Description]:

Mifamurtide (sodium hydrate) (MTP-PE (sodium hydrate); L-MTP-PE (sodium hydrate); CGP 19835 (sodium hydrate)) is the sodium hydrate of mifamurtide. Mifamurtide is a nonspecific immunomodulator that acts by stimulating immune responses by activating macrophages and monocytes. Mifamurtide is a specific ligand for NOD2 and is used as an insulin sensitizer and may also be used in osteosarcoma research[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Kevin Biteau, et al. L-MTP-PE and zoledronic acid combination in osteosarcoma: preclinical evidence of positive therapeutic combination for clinical transfer. Am J Cancer Res. 2016 Feb 15;6(3):677-89.  

[2]. Mifamurtide: CGP 19835, CGP 19835A, L-MTP-PE, liposomal MTP-PE, MLV 19835A, MTP-PE, muramyltripeptide phosphatidylethanolamine. Drugs R D, 2008. 9(2): p. 131-5.  

[3]. Joseph F Cavallari, et al. Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4. Cell Metab. 2017 May 2;25(5):1063-1074.e3.  

Chemical & Physical Properties

[ Molecular Formula ]:
C59H110N6NaO20P

[ Molecular Weight ]:
1277.496

[ Exact Mass ]:
1276.740967

Related Compounds

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