NSC 33994

Names

[ CAS No. ]:
82058-16-0

[ Name ]:
NSC 33994

[Synonym ]:
4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]phenol
(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
4,4 inverted exclamation marka-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}

Biological Activity

[Description]:

NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

[Target]

JAK2:60 nM (IC50, JAK2 Val617Phe kinase activity )

[In Vitro]

NSC 33994 (G6) reduces the levels of phospho-JAK2 in both a dose- and time-dependent manner[1]. NSC 33994 (G6, 0-25 μM, 0-48 h) inhibits phospho-JAK2 (pY1007/pY1008) in a dose-dependent and time-dependent manner[1].

[References]

[1]. Róbert Kiss, et al. Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3598-601.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₄₂N₂O₂

[ Molecular Weight ]:
438.64500

[ Exact Mass ]:
438.32500

[ PSA ]:
46.94000

[ LogP ]:
6.51220

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Articles

PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.

Oncotarget 5(15) , 6038-48, (2014)

Protein Tyrosine kinase 6 (PTK6/BRK) is overexpressed in the majority of human breast tumors and breast tumor cell lines. It is also expressed in normal epithelial linings of the gastrointestinal trac...

RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer.

Oncotarget 6 , 11114-24, (2015)

We have demonstrated that RNA-dependent protein kinase (PKR) and its downstream protein p-eIF2α are independent prognostic markers for overall survival in lung cancer. In the current study, we further...

Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.

Toxicol. In Vitro 29(3) , 417-25, (2015)

Plant-derived dietary polyphenolic compounds, such as flavonoids, with cancer cell-specific pro-apoptotic activity and chemopreventive potential are thought to be promising anticancer agents. In the p...