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3α-Hydroxy pravastatin sodium

Names

[ CAS No. ]:
81093-43-8

[ Name ]:
3α-Hydroxy pravastatin sodium

[Synonym ]:
3alpha-Hydroxy Pravastatin Sodium Salt
3|A-Hydroxy Pravastatin Sodium Salt
UNII-TC279YC5KM
Pravastatin related compound A

Biological Activity

[Description]:

3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)

[References]

[1]. Zhang X, Vernikovskaya DI, Wang X, et al. Quantitative determination of pravastatin and its metabolite 3α-hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS. Biomed Chromatogr. 2016;30(4):548‐554.

[2]. Shiomi M, et al. Pravastatin sodium, a competitive inhibitor of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly secreted very-low-density lipoprotein in Watanabe heritable hyperlipidemic rabbits. Metabolism. 1994;43(5):559‐564.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H35NaO7

[ Molecular Weight ]:
446.51000

[ Exact Mass ]:
446.22800

[ PSA ]:
127.12000

[ LogP ]:
1.10570

Safety Information

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Related Compounds