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PTP1B-IN-3

Names

[ CAS No. ]:
809272-64-8

[ Name ]:
PTP1B-IN-3

[Synonym ]:
P-[(3-Bromo-7-cyano-2-naphthalenyl)difluoromethyl]phosphonic Acid
PTP1B-IN-3

Biological Activity

[Description]:

PTP1B-IN-3 is a potent and selective PTP1B inhibitor with IC50s of 120 nM (PTP1B) and 120 nM (TCPTP), respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Metabolic Disease

[Target]

IC50: 120 nM (PTP1B), 120 nM (TCPTP) [1].


[References]

[1]. Patel D, .Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors. ChemMedChem. 2011 Jun 6; 6(6):1011-6.


[Related Small Molecules]

SHP099 hydrochloride | LB-100 | Salubrinal | Calyculin A | SF1670 | Stibogluconate sodium | TPI-1 | MSI-1436 lactate | Microcystin-LR | Sodium orthovanadate | GSK 2830371 | PTP1B-IN-2 | Rosiptor | NSC 663284(DA3003-1) | TCS 401

Chemical & Physical Properties

[ Molecular Formula ]:
C12H7BrF2NO3P

[ Molecular Weight ]:
362.06300

[ Exact Mass ]:
360.93100

[ PSA ]:
91.13000

[ LogP ]:
3.70098

Related Compounds

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