20-hydroxy-20-oxoleukotriene B4
Names
[ CAS No. ]:
80434-82-8
[ Name ]:
20-hydroxy-20-oxoleukotriene B4
[Synonym ]:
(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenedioic acid
20-carboxy-LTB4
20-hydroxy-20-oxoleukotriene B4
5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraene-1,20-dioic acid
6,8,10,14-Eicosatetraenedioic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)-
5,12-Dihydroxy-delta5,8,11,14-eicosapolyendioic acid
20-COOH-LTB4
(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenedioic acid
20-carboxyleukotriene B4
20-COOH-Leukotriene B4
MFCD00065857
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Human Endogenous Metabolite
[References]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
588.3±50.0 °C at 760 mmHg
[ Molecular Formula ]:
C20H30O6
[ Molecular Weight ]:
366.449
[ Flash Point ]:
323.6±26.6 °C
[ Exact Mass ]:
366.204254
[ PSA ]:
115.06000
[ LogP ]:
2.02
[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C
[ Index of Refraction ]:
1.548
MSDS
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H315-H319-H335
[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F,Xi
[ Risk Phrases ]:
11-36/37/38
[ Safety Phrases ]:
16-26-36
[ RIDADR ]:
UN 1170 3/PG 2
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
PLoS ONE 6(2) , e16957, (2011)
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...
Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes.FEBS Lett. 130(1) , 107-12, (1981)
Defective metabolism of leukotriene B4 in the Sjögren-Larsson syndrome.
J. Neurol. Sci. 183(1) , 61-7, (2001)
The Sjögren-Larsson Syndrome (SLS) is a neurocutaneous disorder, caused by deficient activity of the microsomal enzyme fatty aldehyde dehydrogenase (FALDH). FALDH catalyzes the oxidation of medium- an...