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Maytansinoid dM4

Names

[ CAS No. ]:
799840-96-3

[ Name ]:
Maytansinoid dM4

[Synonym ]:
MFCD28144633

Biological Activity

[Description]:

Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[Target]

Maytansinoids


[In Vitro]

Maytansine is a natural benzoansamacrolide product isolated from the bark of the African shrub Maytenus ovatus. Maytansine binds to the same site on tubulin as the vinca alkaloids, with similar in vitro inhibition constants, but is a more-potent cytotoxin[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

[2]. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
940.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C39H56ClN3O10S

[ Molecular Weight ]:
794.394

[ Flash Point ]:
522.4±34.3 °C

[ Exact Mass ]:
793.337463

[ LogP ]:
6.26

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.587

Related Compounds