Pirsue

Names

[ Name ]:
Pirsue

[Synonym ]:
Methyl (5R)-5-[(1S,2S)-2-chloro-1-({[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl}amino)propyl]-1-thio-β-L-arabinopyranoside hydrochloride hydrate
Methyl (2S-cis)-7-Chloro-6,7,8-trideoxy-6-(((4-ethyl-2-piperidinyl)carbonyl)amino)-1-thio-L-threo-a-D-galacto-octopyranoside Monohydrochloride
Methyl 7-chloro-6,7,8-trideoxy-6-({[(2S,4R)-4-ethylpiperidin-2-yl]carbonyl}amino)-1-thio-L-threo-α-D-galacto-octopyranoside hydrochloride hydrate
pirlimycin hydrochloride, antibiotic for culture media use only
pirlimycin
L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-, hydrochloride, hydrate (1:1:1)
Pirsue
U 57903E

Biological Activity

[Description]:

Pirlimycin (RU 38882) hydrochloride, a lincosamide antibiotic, is active against Gram-positive bacteria. Pirlimycin hydrochloride acts by inhibiting bacterial protein synthesis via binding with the 50S subunit of the ribosome[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Birkenmeyer RD, et, al. Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent. J Med Chem. 1984 Feb;27(2):216-23.

Chemical & Physical Properties

[ Melting Point ]:
>160 °C (dec.) (lit.)

[ Molecular Formula ]:
C₁₇H₃₂Cl₂N₂O₅S

[ Molecular Weight ]:
465.433

[ Exact Mass ]:
464.151459

[ PSA ]:
136.35000

[ LogP ]:
1.56900

Related Compounds

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