H-Pro-Gly-Pro-OH

H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia[1][2].

Research Areas >> Others

Signaling Pathways >> Others >> Others

H-Pro-Gly-Pro-OH (37.5 µg/kg; i.p.) 在大鼠脑缺血后激活神经营养蛋白及其受体基因的转录[2]。 Animal Model: 270-320 g, male Wistar rats (focal cerebral ischemia)[2] Dosage: 37.5 µg/kg Administration: I.p.; 15, 1 h, 4, 8, 24, 28, 32, 48, 52, and 56 h Result: Enhanced the transcription of Bdnf and TrkC 3 h after pMCAO and Ngf, TrkB, TrkC, and TrkA 24 h after pMCAO.

[1]. Patel DF, et al. The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27(148):180017.  

[2]. Dmitrieva VG, et al. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol. 2010 Jan;30(1):71-9.