TLSC702

Names

[ Name ]:
TLSC702

[Synonym ]:
MFCD06660558
2-Benzothiazolepropanoic acid, β-[(4-methoxyphenyl)methylene]-, (βZ)-
(3Z)-3-(1,3-Benzothiazol-2-yl)-4-(4-methoxyphenyl)-3-butenoic acid

Biological Activity

[Description]:

TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM; inhibits the proliferation of human leukemia HL-60 cells and induces apoptosis in a dose-dependent manner; more significantly inhibits the proliferation of human lung cancer NCI-H522 cells, which highly express GLO I, than that of GLO I lower-expressing human lung cancer NCI-H460 cells.

[References]

References 1. Takasawa R, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4337-42. 2. Takasawa R, et al. Biol Pharm Bull. 2016;39(5):869-73. 3. Shimada N, et al. Arch Biochem Biophys. 2018 Jan 15;638:1-7. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
547.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₅NO₃S

[ Molecular Weight ]:
325.382

[ Flash Point ]:
284.7±32.9 °C

[ Exact Mass ]:
325.077271

[ LogP ]:
5.44

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.696

Related Compounds

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