Rubiadin 1-methyl ether

Names

[ Name ]:
Rubiadin 1-methyl ether

[Synonym ]:
9,10-Anthracenedione, 3-hydroxy-1-methoxy-2-methyl-
9,10-Anthracenedione,3-hydroxy-1-methoxy-2-methyl
3-Hydroxy-1-methoxy-2-methylanthraquinone
1,3-dimethoxy-2-methylanthraquinone
3-Hydroxy-1-methoxy-2-methyl-anthraquinone
3-Hydroxy-1-methoxy-2-methyl-9,10-anthraquinone
rubiadin-1-methyl ether
3-Hydroxy-1-methoxy-2-methyl-anthrachinon

Biological Activity

[Description]:

Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1].

[Target]

p65

[References]

[1]. He YQ, et al. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochem Biophys Res Commun. 2018 Dec 2;506(4):927-931.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
502.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₂O₄

[ Molecular Weight ]:
268.264

[ Flash Point ]:
193.0±23.6 °C

[ Exact Mass ]:
268.073547

[ PSA ]:
63.60000

[ LogP ]:
3.92

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.649

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914690090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%