Ivachtin

Names

[ Name ]:
Ivachtin

[Synonym ]:
L-Proline, 5-oxo-, compd. with 5-hydroxy-6-methyl-3,4-pyridinedimethanol (1:1)
5-Hydroxy-6-methyl-3,4-pyridinedimethanol,5-Oxo-L-proline
Metadoxil
UNII:EJQ7M98H5J
MFCD08704232
EINECS 277-913-8
Metasin
5-Oxo-L-proline - 4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol (1:1)
Metadoxine

Biological Activity

[Description]:

Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA

Signaling Pathways >> Stem Cell/Wnt >> PKA

Research Areas >> Metabolic Disease

[In Vitro]

Simultaneous Metadoxine treatment notably inhibits adipogenic differentiation in a dose-dependent manner. Metadoxine treatment from day 4 through day 8 is required for inhibition of MDI-induced preadipocyte differentiation[1]. Metadoxine prevents glutathione depletion and the increase in lipid peroxidation damage caused by ethanol and acetaldehyde in HepG2 cells. In hepatic stellate cells, Metadoxine prevents the increase in collagen and attenuated TNF-α secretion caused by acetaldehyde. Thus, Metadoxine could be useful in preventing the damage produced in early stages of alcoholic liver disease as it prevents the redox imbalance of the hepatocytes and prevents TNF-α induction, one of the earliest events in hepatic damage[2].

[References]

[1]. Yang YM, et al. Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway. Arch Biochem Biophys. 2009 Aug 15;488(2):91-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
491.9ºC at 760 mmHg

[ Melting Point ]:
102-104ºC

[ Molecular Formula ]:
C₁₃H₁₈N₂O₆

[ Molecular Weight ]:
298.292

[ Flash Point ]:
251.3ºC

[ Exact Mass ]:
298.116486

[ PSA ]:
139.98000

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2936250000

Customs

[ HS Code ]: 2936250000

[ Summary ]:
HS: 2936250000. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:4.0%. general tariff:20.0%