LY125180

Names

[ CAS No. ]:
74515-39-2

[ Name ]:
LY125180

[Synonym ]:
N,N-dimethyl-3-(4-methylphenoxy)-1-phenylpropan-1-amine hydrochloride

Biological Activity

[Description]:

LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Wong DT, et al. N,N-Dimethyl-alpha-[2-(p-tolyloxy)ethyl]benzylamine hydrochloride (LY125180). Effects on serotonin uptake and serotonin synthesis in rat brain in vitro and in vivo. Biochem Pharmacol. 1980 Mar 15;29(6):935-41.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H24ClNO

[ Molecular Weight ]:
305.84

[ Exact Mass ]:
305.15500

[ PSA ]:
12.47000

[ LogP ]:
4.86880

Related Compounds