O-Desmethyl Midostaurin

Names

[ CAS No. ]:
740816-86-8

[ Name ]:
O-Desmethyl Midostaurin

Biological Activity

[Description]:

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Cancer
Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

IC50: active metabolite of Midostaurin[1]


[References]

[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108(10):3477-83.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H28N4O4

[ Molecular Weight ]:
556.61

[ Storage condition ]:
-20°C

Related Compounds