L-Methionine-13C,d3

Names

[ Name ]:
L-Methionine-13C,d3

[Synonym ]:
S-(Methyl-d3)-L-homocysteine
L-<methyl-13C2H3>methionine
MFCD00002624
(S)-<methyl-13C,2H3>methionine
h-Met-oh-d3
L-Methionine-(methyl-d3)
S-(Methyl-d3)-L-momocysteine
L-methionine-C-d3
Cymethion-d3
|A-(Methyl-d3)thio-|A-aminobutyric Acid
Methionine-d3
l-Methionine-d3
L-<methyl-2H3>methionine
L-<Me-(2)H3>methionine
S-Methionine-d3
(methyl-13C,2H3)methionine

Biological Activity

[Description]:

L-Methionine-13C,d3 is the 13C- and deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Melting Point ]:
273ºC (dec.)(lit.)

[ Molecular Formula ]:
C₄₁₃CH₈D₃NO₂S

[ Molecular Weight ]:
153.22200

[ Exact Mass ]:
153.07300

[ PSA ]:
88.62000

[ LogP ]:
0.85170

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Articles

5-Hydroxymethylcytosine is a predominantly stable DNA modification.

Nature Chemistry 6(12) , 1049-55, (2014)

5-Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine which is present in the deoxyribonucleic acid (DNA) of most mammalian cells. Reduction of hmC levels in DNA is a hallmark of c...

5-Formylcytosine can be a stable DNA modification in mammals.

Nat. Chem. Biol. 11(8) , 555-7, (2015)

5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from th...