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3,5-Difluoro-L-tyrosine

Names

[ CAS No. ]:
73246-30-7

[ Name ]:
3,5-Difluoro-L-tyrosine

[Synonym ]:
3,5-difluoropyridine N-oxide
3,5-difluorotyrosine
3,5-Difluoropyridine 1-oxide

Biological Activity

[Description]:

3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs)[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Others

[In Vitro]

3,5-Difluoro-L-tyrosine (F2Y) is a fluorinated tyrosine analog. 3,5-Difluoro-L-tyrosine is compatible with every aspect of library synthesis, screening, and sequence identification. 3,5-Difluoro-L-tyrosine is a good functional mimic of tyrosine, in terms of binding to the active site of PTPs[1].

[References]

[1]. Bhaskar Gopishetty, et al. Synthesis of 3,5-difluorotyrosine-containing peptides: application in substrate profiling of protein tyrosine phosphatases. Org Lett. 2008 Oct 16;10(20):4605-8.

Chemical & Physical Properties

[ Density]:
1.475 g/cm3

[ Boiling Point ]:
387.9ºC at 760 mmHg

[ Molecular Formula ]:
C9H9F2NO3

[ Molecular Weight ]:
217.16900

[ Flash Point ]:
188.4ºC

[ Exact Mass ]:
217.05500

[ PSA ]:
83.55000

[ LogP ]:
1.32510

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Precursor & DownStream


Related Compounds