Somatostatin-28 trifluoroacetate salt

Names

[ Name ]:
Somatostatin-28 trifluoroacetate salt

[Synonym ]:
Somatostatin-28
Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys
Somatostatin 28,Cyclic
MFCD00076772
Somatostatin-28 (sheep) 28

Biological Activity

[Description]:

Somatostatin-28 (sheep) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

Research Areas >> Metabolic Disease

[Target]

SSTR5

[In Vitro]

Somatostatin-28 剂量依赖地抑制胃泌素释放肽刺激的 GLP-1 分泌，EC50 为 0.01 nM[1]。

[In Vivo]

Somatostatin-28 (sheep) (1.1 pmol/kg/min; 通过颈静脉导管静脉注射; 15 min) 抑制 25 μg/kg/min 葡萄糖诱导绵羊胰岛素分泌[2]。 Animal Model: Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)[2] Dosage: 1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose; Administration: Intravenous injection via a jugular catheter; Result: Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.

[References]

[1]. Martin PA, et al. Effects of somatostatin-28 on circulating concentrations of insulin and gut hormones in sheep. J Endocrinol. 1996 Oct;151(1):107-12.

[2]. Chisholm C, et al. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E311-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃₇H₂₀₇N₄₁O₃₉S₃

[ Molecular Weight ]:
3148.56000

[ Exact Mass ]:
3146.46000

[ PSA ]:
1392.71000

[ LogP ]:
0.20370

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Somatostatin and its receptor family.

Front. Neuroendocrinol. 20 , 157-198, (1999)

Somatostatin (SST), a regulatory peptide, is produced by neuroendocrine, inflammatory, and immune cells in response to ions, nutrients, neuropeptides, neurotransmitters, thyroid and steroid hormones, ...

Somatostatin receptor subtype-5 mediates inhibition of peptide YY secretion from rat intestinal cultures.

Am. J. Physiol. 279 , G983-G989, (2000)

Somatostatin-14 (S-14) and somatostatin-28 (S-28) bind to five distinct membrane receptors (SSTRs), but S-28 has higher affinity for SSTR-5. Whether S-28 acting through SSTR-5 regulates inhibition of ...

Intracisternal injection of somatostatin receptor 5-preferring agonists induces a vagal cholinergic stimulation of gastric emptying in rats.

J. Pharmacol. Exp. Ther. 293 , 1099-1105, (2000)

We previously showed that the somatostatin receptor 5 (sst(5))-preferring agonist BIM-23052 injected intracisternally (i.c. ; 0.8 nmol/rat) stimulated gastric emptying of a non-nutrient meal in consci...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.