L-Aspartic acid,3-hydroxy-, (3S)-

Names

[ Name ]:
L-Aspartic acid,3-hydroxy-, (3S)-

[Synonym ]:
(2S,3S)-2-amino-3-hydroxybutanedioic acid
W-7 hydrochloride

Biological Activity

[Description]:

L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2

Research Areas >> Neurological Disease

[Target]

Ki: 11 μM (EAAT1), 14 μM (EAAT3), 19 μM (EAAT2)[1]

[References]

[1]. HaraR, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-DeficientEscherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolorA3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54

[2]. Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27.

Chemical & Physical Properties

[ Density]:
1.738 g/cm3

[ Boiling Point ]:
368.7ºCat 760 mmHg

[ Molecular Formula ]:
C₄H₇NO₅

[ Molecular Weight ]:
149.10

[ Flash Point ]:
176.8ºC

[ Exact Mass ]:
149.03200

[ PSA ]:
120.85000

[ Storage condition ]:
Store at RT

Related Compounds

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