trans-Zeatin-d5

Names

[ CAS No. ]:
72963-19-0

[ Name ]:
trans-Zeatin-d5

Biological Activity

[Description]:

trans-Zeatin-d5 is deuterium labeled trans-Zeatin. trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation.

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> MEK
Research Areas >> Others
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Li Q, et al. Endogenous trans-zeatin content in plants with different metal-accumulating ability: a field survey. Environ Sci Pollut Res Int. 2016 Dec;23(23):23422-23435. Epub 2016 Sep 9.

[3]. Ji C, et al. Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes. Int J Mol Med. 2010 Aug;26(2):257-63.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H8D5N5O

[ Molecular Weight ]:
224.27

Related Compounds