N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide

Names

[ CAS No. ]:
727699-84-5

[ Name ]:
N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide

[Synonym ]:
MLS000417014
N-(3-(4-fluorophenylsulfonamido)-4-methoxyphenyl)-[1,1'-biphenyl]-4-carboxamide

Biological Activity

[Description]:

SN-001 is a STING inhibitor with an IC50 of 3.82 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> STING

[Target]

IC50: 3.82 μM (STING)[1]

[In Vitro]

SN-001 targets the cyclic dinucleotide binding pocket of human STING[1]. SN-001 (5-20 μM; 6 h) significantly impairs the induction of Ifnb mRNA, in a dose-dependent manner in L929 cells[1]. SN-001 (10 μM; 3 h) inhibits cytosolic DNA-triggered STING signaling[1]. Western Blot Analysis[1] Cell Line: L929 cells Concentration: 10 μM Incubation Time: 3 h Result: Decreased cytosolic DNA-induced phosphorylation of STING, TBK1, IRF3, IκBα, and p65, as well as nuclear translocation of IRF3 and p65.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₁FN₂O₄S

[ Molecular Weight ]:
476.522

[ Exact Mass ]:
476.121

Related Compounds

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