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Phenethyl ferulate

Names

[ CAS No. ]:
71835-85-3

[ Name ]:
Phenethyl ferulate

[Synonym ]:
Phenyethyl 3-methylcaffeate
2-Phenylethyl 3-(4-hydroxy-3-methoxyphenyl)-2-propenoate
2-phenylethyl (2E)-3-[4-hydroxy-3-(methyloxy)phenyl]prop-2-enoate
Phenylethyl 3-methylcaffeate
Caffeic Acid 3-Methyl Phenethyl Ester
2-Propenoic acid,3-(4-hydroxy-3-methoxyphenyl)-,2-phenylethyl ester

Biological Activity

[Description]:

Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC50 values of 4.35 μM and 5.75 μM, respectively[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX
Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

COX:4.35 μM (IC50)

5-LOX:5.75 μM (IC50)


[References]

[1]. S Zschocke, et al. 5-Lipoxygenase and cyclooxygenase inhibitory active constituents from Qianghuo (Notopterygium incisum). Planta Med. 1997 Jun;63(3):203-6.

Chemical & Physical Properties

[ Density]:
1.193g/cm3

[ Boiling Point ]:
474.7ºC at 760 mmHg

[ Melting Point ]:
81℃

[ Molecular Formula ]:
C18H20O4

[ Molecular Weight ]:
300.34900

[ Flash Point ]:
171.6ºC

[ Exact Mass ]:
300.13600

[ PSA ]:
55.76000

[ LogP ]:
3.11930

[ Index of Refraction ]:
1.606

Related Compounds