Tocainide hydrochloride

Names

[ Name ]:
Tocainide hydrochloride

[Synonym ]:
(+-)-2-amino-N-(2,6-dimethylphenyl)propionamide hydrochloride
4-Amino-2-[4,6-diamino-3-[3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol sulfate
Tobramycin sulfate [usan]
Tocainidhydrochlorid
6'-propionoxylidide hydrochloride
TOBRAMYCIN SULPHATE

Biological Activity

[Description]:

Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Inflammation/Immunology

[Target]

IC50: sodium channel[1]

[In Vivo]

Tocainide (100 mg/kg) effectively suppresses ventricular ectopic activity in unanesthetized dogs with coronary occlusion. Termination of tocainide infusion in both digitalis toxicity and coronary occlusion models results in prompt return of ventricular ectopic activity[1].

[References]

[1]. Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3(6):316-23.

[2]. De Luca A,et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64(4):932-45.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₇ClN₂O

[ Molecular Weight ]:
192.25800

[ Exact Mass ]:
192.12600

[ PSA ]:
55.12000

[ LogP ]:
2.36240

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Articles

Synthesis, structure and pharmacology of acyl-2,6-xylidines.

Acta Pol. Pharm. 61(3) , 215-21, (2004)

L-2-perhydroheterocyclicalkyl acids were condensed with 2,6-xylidine. 8 new optically active acyl-2,6-xylidines were obtained. Absolute configuration of acyl-2,6-xylidines were selected for pharmacolo...

Quantitative structure-pharmacokinetic relationships for drug clearance by using statistical learning methods.

J. Mol. Graph. Model. 24(5) , 383-95, (2006)

Quantitative structure-pharmacokinetic relationships (QSPkR) have increasingly been used for the prediction of the pharmacokinetic properties of drug leads. Several QSPkR models have been developed to...

The efficacy of anticonvulsants on orofacial pain: a systematic review.

Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 111(5) , 627-33, (2011)

Controversy exists about the effectiveness of anticonvulsants for the management of orofacial pain disorders. To ascertain appropriate therapies, a systematic review was conducted of existing randomiz...