Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility drugs. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg[1].

Research Areas >> Others

Hydroxypropylmethyl cellulose acetate succinate（2.5 g/kg；p.o.；单剂量）在大鼠无显著急性毒性[1]。 Hydroxypropylmethyl cellulose acetate succinate（0.63、1.25、2.5 g/kg；p.o.；每日一次，连续 2 个月，每周 6 天）在大鼠无显著亚慢性毒性[1]。 Hydroxypropylmethyl cellulose acetate succinate（1.25 g/kg、2.5 g/kg；口服；每天一次，连续 2 个月，每周 6 天）在大鼠无显著慢性毒性[1]。

[1]. Hoshi N, et al. Toxicological studies of hydroxypropylmethylcellulose acetate succinate--acute toxicity in rats and rabbits, and subchronic and chronic toxicities in rats. J Toxicol Sci. 1985 Oct;10 Suppl 2:147-85.