Etilefrin

Names

[ CAS No. ]:
709-55-7

[ Name ]:
Etilefrin

[Synonym ]:
ethylphenylarsine chloride
Aethyl-chlor-phenyl-arsin
Arsine,chloroethylphenyl-(6CI,7CI,8CI)
Arsinous chloride,ethylphenyl
ethylphenylephrine
Aethyl-phenyl-dithiocarbamidsaeure,Ammonium-Salz
ethyl(phenyl)arsinous chloride
Aethylphenylarsinchlorid
Aethylphenylarsenchlorid
ethyl-chloro-phenyl-arsine
ammonium N-ethyl-N-phenyldithiocarbamate
Chloroethylphenylarsine
(RS)-etilefrine
2-ethylamino-1-(3-hydroxy-phenyl)-ethanol
ethyl-phenyl-dithiocarbamic acid,ammonium salt
Aethyl-phenyl-chlor-arsin
[3H]-(+/-)-Etilefrine
Ethylphenylchloroarsine

Biological Activity

[Description]:

Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist[2]. Etilefrine also is an AMPK activator[1]. Etilefrine can be used for the research of postural hypotension[3].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

[Target]

AMPK

[In Vivo]

Etilefrine (0.1 mg/kg; i.v.) increases blood pressure (BP) and heart rate (HR), however, Etilefrine does not attenuate the decrease in BP induced by the tilt. Etilefrine also tends to increase cardiac output (CO)[3].

[References]

[1]. Sylvain Tollis, et al. Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion. ACS Chem Biol. 2022 Feb 24.

[2]. Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25(2):523-535.e5.

[3]. R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13(9):519-24.

Chemical & Physical Properties

[ Density]:
1.127 g/cm3

[ Boiling Point ]:
351.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₅NO₂

[ Molecular Weight ]:
181.23200

[ Flash Point ]:
155.5ºC

[ Exact Mass ]:
181.11000

[ PSA ]:
52.49000

[ LogP ]:
1.42600

[ Index of Refraction ]:
1.561

Safety Information

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%