H-Phe-Leu-Glu-Glu-Leu-OH

Names

[ Name ]:
H-Phe-Leu-Glu-Glu-Leu-OH

[Synonym ]:
PHE-LEU-GLU-GLU-LEU
FLEEL
phenylalanine-leucine-glutamine-glutamine-leucine
MFCD00076877

Biological Activity

[Description]:

H-Phe-Leu-Glu-Glu-Leu-OH is a synthetic pentapeptide, which can be used as the substrate of vitamin K dependent carboxylase, and a glutamyl residue in the generated product is carboxylated[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Rich DH, et al. Synthesis of peptide analogues of prothrombin precursor sequence 5-9. Substrate specificity of vitamin K dependent carboxylase. J Med Chem. 1981 Jun;24(6):706-11.

[2]. Rich DH, et al. Synthesis and biological properties of new hexapeptide substrates for vitamin K dependent carboxylase. Evidence for X-Pro cis/trans amide bond interconversions in prothrombin precursor fragment 18-23. J Med Chem. 1983 Jun;26(6):910-6.

Chemical & Physical Properties

[ Density]:
1.259g/cm3

[ Boiling Point ]:
1059.8ºC at 760 mmHg

[ Molecular Formula ]:
C₃₁H₄₇N₅O₁₀

[ Molecular Weight ]:
649.73

[ Flash Point ]:
594.8ºC

[ Exact Mass ]:
649.33200

[ PSA ]:
254.32000

[ LogP ]:
2.66590

[ Index of Refraction ]:
1.551

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile.

Eur. J. Biochem. 269 , 6162-6172, (2002)

The marine snail Conus is the sole invertebrate wherein both the vitamin K-dependent carboxylase and its product, gamma-carboxyglutamic acid, have been identified. To examine its biosynthesis of gamma...

Isolation and partial characterization of a vitamin K-dependent carboxylase from bovine aortae.

Biochem. J. 245 , 251-255, (1987)

Vitamin K-dependent carboxylase activity has been demonstrated in the crude microsomal fraction of the intima of bovine aortae. The procedure for the isolation of vessel wall carboxylase is a slight m...

Vitamin K-dependent carboxylase: purification of the rat liver microsomal enzyme.

Arch. Biochem. Biophys. 202 , 515, (1980)

Related Compounds

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