17-PA

Names

[ Name ]:
17-PA

[Synonym ]:
Budesonide
Respules
Spirocort
Bidien
2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a-dimethyl-8-propyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-
Budesonide,(11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
S-1320
16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
Budeson
Micronyl
Pulmicort
17-PA
ENTOCORT
Rhinocort
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-
PREFERID
2-BFI hydrochloride

Biological Activity

[Description]:

17-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Mennerick S, et al. Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Mol Pharmacol. 2004 May;65(5):1191-7.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
599.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₃₄O₆

[ Molecular Weight ]:
430.534

[ Flash Point ]:
201.8±23.6 °C

[ Exact Mass ]:
430.235535

[ PSA ]:
20.23000

[ LogP ]:
3.14

[ Vapour Pressure ]:
0.0±3.9 mmHg at 25°C

[ Index of Refraction ]:
1.592

Related Compounds

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