Balapiravir hydrochloride

Names

[ Name ]:
Balapiravir hydrochloride

[Synonym ]:
Balapiravir hydrochloride

Biological Activity

[Description]:

Balapiravir hydrochloride (Ro 4588161 hydrochloride; R1626 hydrochloride) is an orally active prodrug of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir hydrochloride has anti-HCV activity[1][2][3].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

After oral dosing of the CD-1 mice with 28.1 mg/kg of balapiravir (Ro 4588161 hydrochloride; R1626 hydrochloride), R1479 reaches a Cmax and a minimum concentration in plasma (Cmin) of 24.38 μM and 6.34 μM, respectively, at 2 h and 24 h postdosing[3].

[References]

[1]. Nguyen NM, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis. 2013 May 1;207(9):1442-1450.

[2]. Nelson DR, et al. Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients.Ann Hepatol. 2012 Jan-Feb;11(1):15-31.

[3]. Yen-Liang Chen, et al. Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir. J Virol. 2014 Feb;88(3):1740-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₁ClN₆O₈

[ Molecular Weight ]:
530.95900

[ Exact Mass ]:
530.18900

[ PSA ]:
199.78000

[ LogP ]:
2.29286

Related Compounds

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