(E/Z)-4-hydroxy Tamoxifen

Names

[ Name ]:
(E/Z)-4-hydroxy Tamoxifen

[Synonym ]:
Propiophenone,4'-[2-(diethylamino)ethoxy]-,hydrochloride
1-[4-(2-Diaethylamino-aethoxy)-phenyl]-propan-1-on,Hydrochlorid
1-[4-(2-diethylaminoethyloxy)phenyl]propan-1-one hydrochloride
4-hydroxytamoxifene
1-[4-(2-dimethylaminoethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenylbut-1-ene
(E,Z)-4-hydroxytamoxifen
1-[4-(2-diethylamino-ethoxy)-phenyl]-propan-1-one,hydrochloride

Biological Activity

[Description]:

(E/Z)-4-Hydroxytamoxifen is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is an estrogen receptor modulator.

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Cancer

[Target]

Estrogen receptor

Chemical & Physical Properties

[ Density]:
1.092

[ Melting Point ]:
135-144°C

[ Molecular Formula ]:
C₂₆H₂₉NO₂

[ Molecular Weight ]:
387.51400

[ Exact Mass ]:
387.22000

[ PSA ]:
32.70000

[ LogP ]:
5.70170

[ Appearance of Characters ]:
white to off-white

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
methanol: soluble10mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332-H361

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
63-20/21/22

[ Safety Phrases ]:
22-23-36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
SL1210000

Precursor & DownStream

Precursor

DownStream

Articles

Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression.

Breast Cancer Res. 17 , 26, (2015)

The emergence of hormone therapy resistance, despite continued expression of the estrogen receptor (ER), is a major challenge to curing breast cancer. Recent clinical studies suggest that epigenetic m...

Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.

BMC Cancer 14 , 853, (2014)

The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. H...

Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.

PLoS ONE 9(10) , e111186, (2014)

Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive prote...