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aurantio-obtusin

Names

[ CAS No. ]:
67979-25-3

[ Name ]:
aurantio-obtusin

[Synonym ]:
9,10-Anthracenedione, 1,3,7-trihydroxy-2,8-dimethoxy-6-methyl-
aurantio-obtusin
1,3,7-trihydroxy-2,8-dimethoxy-6-methylanthracene-9,10-dione
1,3,7-Trihydroxy-2,8-dimethoxy-6-methyl-9,10-anthraquinone

Biological Activity

[Description]:

Aurantio-obtusin is an anthraquinone isolated from Semen Cassiae, with anti-Inflammatory, anti-oxidative, anti-coagulating and anti-hypertension activities[1][2][3]. Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats, thus acts as a new potential vasodilator[2]. Aurantio-obtusin inhibits allergic responses in IgE-mediated mast cells and anaphylactic models and is potential for treatment for allergy-related diseases[3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Hou J, et al. Anti-Inflammatory Effects of Aurantio-Obtusin from Seed of Cassia obtusifolia L. through Modulation of the NF-κB Pathway. Molecules. 2018 Nov 27;23(12).

[2]. Li S, et al. Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats. J Pharmacol Sci. 2015 Jul;128(3):108-15.

[3]. Kim M, et al. Cassia tora Seed Extract and Its Active Compound Aurantio-obtusin Inhibit Allergic Responses in IgE-Mediated Mast Cells and Anaphylactic Models. J Agric Food Chem. 2015 Oct 21;63(41):9037-46.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
594.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H14O7

[ Molecular Weight ]:
330.289

[ Flash Point ]:
222.4±23.6 °C

[ Exact Mass ]:
330.073944

[ PSA ]:
113.29000

[ LogP ]:
3.81

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.679

[ Storage condition ]:
2~8℃

Safety Information

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
24/25

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds