(Deamino-Pen1,Tyr(Me)2, Arg8)-Vasopressin trifluoroacetate salt

Names

[ Name ]:
(Deamino-Pen1,Tyr(Me)2, Arg8)-Vasopressin trifluoroacetate salt

[Synonym ]:
vasopressin deamino-Pen1,O-Me-tyrosine-2,arginine-8
(DEAMINO-PEN1,TYR(ME)2,ARG8)-VASOPRESSIN
3-mercapto-3-methyl-butyryl-tyr(me)-phe-gln-asn-cys-pro-arg-gly-nh2
[Pmp1,Tyr(OMe)2,Arg8] Vasopressin

Biological Activity

[Description]:

Dp[Tyr(methyl)2,Arg8]-Vasopressin is a non-selective peptide arginine vasopressin Vlb receptor antagonist[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor

Research Areas >> Metabolic Disease

[References]

[1]. Kamal A. Al-Barazanji. Use of vasopressin receptor antagonist for regulation of acth release. WO1997035602A1.

Chemical & Physical Properties

[ Density]:
1.49g/cm3

[ Molecular Formula ]:
C₄₉H₇₀N₁₄O₁₂S₂

[ Molecular Weight ]:
1111.30

[ Exact Mass ]:
1110.47000

[ PSA ]:
475.01000

[ LogP ]:
2.60510

[ Index of Refraction ]:
1.684

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H332

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Articles

Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems.

Nature 337(6208) , 648-51, (1989)

Growth factors raise intracellular pH (pHi) by stimulating Na+/H+ exchange in the absence of HCO3-. In mutant cells that lack the Na+/H+ exchange activity, this alkalinization does not occur, and the ...

Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled study.

Circulation 107(18) , 2313-9, (2003)

Vasodilatory shock is a potentially lethal complication of severe disease in critically ill patients. Currently, catecholamines are the most widely used vasopressor agents to support blood pressure, b...

Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia.

J. Cereb. Blood Flow Metab. 25(8) , 1012-9, (2005)

Brain edema formation is one of the most important mechanisms responsible for brain damage after ischemic stroke. Despite considerable efforts, no specific therapy is available yet. Arginine vasopress...