Mizagliflozin

Names

[ Name ]:
Mizagliflozin

[Synonym ]:
mizagliflozin
KGA-3235
DSP-3235
Propanamide, 3-[[3-[4-[[3-(β-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl]methyl]-3-methylphenoxy]propyl]amino]-2,2-dimethyl-
3-{[3-(4-{[3-(β-D-Glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-yl]methyl}-3-methylphenoxy)propyl]amino}-2,2-dimethylpropanamide
1X96A704XV
10245
GSK-1614235

Biological Activity

[Description]:

Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, selective, orally active SGLT1 inhibitor with Ki of 27 nM, displays >350-fold selectivity over SGLT2; increases stool frequency and loosens stool consistency in phase I study; increases fecal wet weight in a dog model of loperamide-induced constipation and a rat model of low-fiber-diet-induced constipation, similar to lubiprostone. Diabetes Phase 1 Clinical

[References]

References 1. Inoue T, et al. Eur J Pharmacol. 2017 Jul 5;806:25-31. View Related Products by Target SGLT Diabetes

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
837.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₄₄N₄O₈

[ Molecular Weight ]:
564.671

[ Flash Point ]:
460.0±34.3 °C

[ Exact Mass ]:
564.315918

[ LogP ]:
0.59

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.588

[ Storage condition ]:
2-8°C

Related Compounds

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