Guttiferone G

Names

[ Name ]:
Guttiferone G

Biological Activity

[Description]:

Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

IC50: 9 and 22 μM (SIRT1/2)[1]

[References]

[1]. Williams RB, et al. A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest. Planta Med. 2003 Sep;69(9):864-6.

[2]. Gey C, et al. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angew Chem Int Ed Engl. 2007;46(27):5219-22.

Chemical & Physical Properties

[ Density]:
1.088±0.06 g/cm3(Predicted)

[ Boiling Point ]:
756.4±60.0 °C(Predicted)

[ Molecular Formula ]:
C₄₃H₅₈O₆

[ Molecular Weight ]:
670.92

Related Compounds

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