4-tert-butyl-2-((cyclohexylamino)methyl)-6-methylphenol

Names

[ Name ]:
4-tert-butyl-2-((cyclohexylamino)methyl)-6-methylphenol

[Synonym ]:
4-tert-Butyl-2-cyclohexylaminomethyl-6-methyl-phenol

Biological Activity

[Description]:

NSC 48160 inhibits the growth of the pancreatic cancer cells with IC50s of 84.3 μM for CPFAC-1 and 94.5 μM for BxPC-3. NSC 48160 also induces pancreatic cancer cell apoptosis. NSC 48160 can improve metabolic syndromes, such as NASH, obesity and lipid metabolism disorders[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Li D, et al. A small-molecule induces apoptosis and suppresses metastasis in pancreatic cancer cells. Eur J Pharm Sci. 2013 Mar 12;48(4-5):658-67.

[2]. Liu zuijia, et al. Application of small molecule compound NSC48160 in preparation of medicine for treating non-alcoholic fatty liver disease. Patent. CN115869292

Chemical & Physical Properties

[ Density]:
1g/cm3

[ Boiling Point ]:
387.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₉NO

[ Molecular Weight ]:
275.42900

[ Flash Point ]:
67.2ºC

[ Exact Mass ]:
275.22500

[ PSA ]:
32.26000

[ LogP ]:
4.81130

[ Index of Refraction ]:
1.538

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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