<Suppliers Price>

Tigloylgomisin H

Names

[ CAS No. ]:
66069-55-4

[ Name ]:
Tigloylgomisin H

[Synonym ]:
UNII:563Q173U7G
TIGLOYLGOMISIN H
563Q173U7G
(6S,7S)-7-Hydroxy-2,3,10,11,12-pentamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-1-yl (2E)-2-methyl-2-butenoate
2-Butenoic acid, 2-methyl-, (6S,7S)-5,6,7,8-tetrahydro-7-hydroxy-2,3,10,11,12-pentamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-1-yl ester, (2E)-

Biological Activity

[Description]:

Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
656.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C28H36O8

[ Molecular Weight ]:
500.581

[ Flash Point ]:
212.3±25.0 °C

[ Exact Mass ]:
500.241028

[ LogP ]:
4.92

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.539

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds