H-D-Arg(NO2)-OH

Names

[ Name ]:
H-D-Arg(NO2)-OH

[Synonym ]:
MFCD00066013
L-Ornithine, N-[(E)-imino(nitroamino)methyl]-
D-Ornithine, N-[amino(nitroamino)methylene]-, (E)-
N-ω-NITRO-L-ARGININE
(E)-N-[Amino(nitroamino)methylene]-D-ornithine
N'-Nitro-D-arginine
H-Arg(NO2)-OH
L-Ornithine, N5-(imino(nitroamino)methyl)-
N-(N-Nitrocarbamimidoyl)-L-ornithine
H-D-Arg(NO2)-OH
Ng-Nitro-D-arginine

Biological Activity

[Description]:

N'-Nitro-D-arginine (NOLA), a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) [1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[In Vivo]

N'-Nitro-D-arginine (NOLA) (40 mg/ kg) produces a significant increase in systolic blood pressure in the chronic, awake, instrumented sheep model[1].

[References]

[1]. C K Narkowicz, et al. Delayed recovery from NG-nitro-L-arginine in the conscious sheep. Clin Exp Pharmacol Physiol. 1991 Dec;18(12):843-6.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
462.4±55.0 °C at 760 mmHg

[ Melting Point ]:
>220ºC

[ Molecular Formula ]:
C₆H₁₃N₅O₄

[ Molecular Weight ]:
219.199

[ Flash Point ]:
233.5±31.5 °C

[ Exact Mass ]:
219.096756

[ PSA ]:
157.05000

[ LogP ]:
-0.79

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.638

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2925290090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%