m-PEG9-SH

Names

[ CAS No. ]:
651042-84-1

[ Name ]:
m-PEG9-SH

[Synonym ]:
2,5,8,11,14,17,20,23,26-nonaoxaoctacosane-28-thiol

Biological Activity

[Description]:

m-PEG9-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.075

[ Molecular Formula ]:
C₁₉H₄₀O₉S

[ Molecular Weight ]:
444.58100

[ Exact Mass ]:
444.23900

[ PSA ]:
121.87000

[ LogP ]:
0.69540

[ Storage condition ]:
2-8°C

Related Compounds

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