Gabapentin-lactam

Names

[ Name ]:
Gabapentin-lactam

[Synonym ]:
Pentamethylene pyrrolidinone
4,4-pentamethylene-2-pyrrolidone
2-AZASPIRO-(4,5)-DECAN-3-ONE
3,3-Pentamethylene-4-butyrolac
3,3-Pentenylene-4-butyrolactam
Gabapentin Related Compound A
4,4-Pentamethylene-2-pyrrolidinone
MFCD00177938
GABA-pentinlactam
EINECS 451-630-1
forgabapentine
Gabapentin Impurity 1

Chemical & Physical Properties

[ Density]:
1.05 g/cm3

[ Boiling Point ]:
181 °C / 13mmHg

[ Melting Point ]:
84-89 °C(lit.)

[ Molecular Formula ]:
C₉H₁₅NO

[ Molecular Weight ]:
153.22100

[ Flash Point ]:
192.3ºC

[ Exact Mass ]:
153.11500

[ PSA ]:
29.10000

[ LogP ]:
1.78560

[ Index of Refraction ]:
1.509

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CM0120000

CHEMICAL NAME :: 2-Azaspiro(4,5)decan-3-one

CAS REGISTRY NUMBER :: 64744-50-9

BEILSTEIN REFERENCE NO. :: 0119500

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H15-N-O

MOLECULAR WEIGHT :: 153.25

WISWESSER LINE NOTATION :: T5MV DXTJ D-& AL6XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,243,1960

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CM0120000

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

Strategies to prevent the neuropsychiatric side-effects of corticosteroids: a case report and review of the literature.

Curr. Opin. Organ Transplant. 19(2) , 201-8, (2014)

The use of corticosteroids is increasing, and while the physical complications of their use are well known, the neuropsychiatric consequences are not. This review focuses on preventing these neuropsyc...

Patient demographics and health plan paid costs in chronic inflammatory demyelinating polyneuropathy.

Muscle Nerve 50(1) , 47-51, (2014)

We determined health plan paid costs and healthcare resource usage of patients with chronic inflammatory demyelinating polyneuropathy (CIDP).CIDP patients from 9 U.S. commercial health plans with clai...

Clinical practice. Postherpetic neuralgia.

N. Engl. J. Med. 371(16) , 1526-33, (2014)