Ro 04-5595 hydrochloride

Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (Ki: 31 nM)[1].

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

GluN2B:31 nM (Ki)

Ro 04-5595 hydrochloride (5-20 mg/kg，i.p.) 抑制 MA 诱导的小鼠中运动刺激[2]。 Ro 04-5595 hydrochloride (10mg/kg，i.p.，持续 6 天) 降低可卡因给药大鼠的 AMPA 与 NMDA 比率[3]。 Animal Model: Methamphetamine (MA) treated mice[1] Dosage: 3-30 mg/kg Administration: i.p., given 30 min before injection of MA (2 mg/kg, i.p.) Result: Dose-dependently decreased MA-induced locomotor activity.

[1]. Mutel V, et al. In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J Neurochem. 1998 May;70(5):2147-55.  

[2]. Li MH, et al. Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology. 2017 Jun;42(7):1539-1547.  

[3]. deBacker J, et al. GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats. Neuropsychopharmacology. 2015 Jan;40(2):394-405.