Anti-inflammatory agent 11

Names

[ Name ]:
Anti-inflammatory agent 11

[Synonym ]:
4-benzyl-1-(4-pyridylcarbonyl)thiosemicarbazide
4-benzyl-1-isonicotinoyl-thiosemicarbazide
4-benzyl-1-(4-pyridoyl) thiosemicarbazide

Biological Activity

[Description]:

Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

TNF-α

[In Vitro]

Anti-inflammatory agent 11 (compound 16) is active in the reduction of accumulated nitrite, with an IC50 of 64.8 ± 1.0 μM[1].

[References]

[1]. Calixto SD, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₄N₄OS

[ Molecular Weight ]:
286.35

[ Exact Mass ]:
286.08900

[ PSA ]:
98.14000

[ LogP ]:
2.56340

Related Compounds

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