4-Methylphenylhydrazine hydrochloride
Names
[ CAS No. ]:
637-60-5
[ Name ]:
4-Methylphenylhydrazine hydrochloride
[Synonym ]:
P-methylphenylhydrazine hydrochloride
Hydrazine, p-tolyl-, monohydrochloride (8CI)
(4-Methylphenyl)hydrazinium chloride
EINECS 211-295-2
(4-methylphenyl)hydrazine hydrochloride
4-Methyl Phenyl Hydrazine Hydrochloride
Hydrazine, (4-methylphenyl)-, hydrochloride (1:1)
(4-Methylphenyl)hydrazinhydrochlorid
4-Methylphenylhydrazine hydrochloride
(4-Methylphenyl)hydrazine hydrochloride (1:1)
MFCD00012940
Chemical & Physical Properties
[ Density]:
1.18
[ Boiling Point ]:
242.8ºC at 760 mmHg
[ Melting Point ]:
241 ºC
[ Molecular Formula ]:
C7H11ClN2
[ Molecular Weight ]:
158.629
[ Flash Point ]:
115.3ºC
[ Exact Mass ]:
158.061081
[ PSA ]:
38.05000
[ LogP ]:
2.85590
[ Water Solubility ]:
soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MW0195000
- CHEMICAL NAME :
- Hydrazine, p-tolyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 637-60-5
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C7-H10-N2.Cl-H
- MOLECULAR WEIGHT :
- 158.65
- WISWESSER LINE NOTATION :
- ZMR D1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 262 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 237 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - hair
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1750 mg/kg/7W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3640 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1400 mg/kg/10W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 800 ug/plate
- REFERENCE :
- NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946- Volume(issue)/page/year: 33,474,1978
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H315-H319-H335
[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R36/37/38;R40
[ Safety Phrases ]:
S26-S36-S36/37/39
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
MW0195000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
29280090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2928000090
[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
Articles
J. Am. Chem. Soc. 130(18) , 5840-1, (2008)
An unexpected reaction of N,N-disubstituted hydrazine with naphthol and its analogues under simply thermal conditions has been disclosed. 2-Naphthol reacted with various N,N-disubstituted hydrazines u...
Studies of the tumorigenic potential of 4-substituted phenylhydrazines by the subcutaneous route.J. Toxicol. Environ. Health A 8(1-2) , 1-9, (1981)
4-Methylphenylhydrazine hydrochloride (4-MPH) was administered to randomly bred Swiss mice as 26 weekly sc injections of 140 microgram per gram of body weight and N'-acetyl-4-(hydroxymethyl)phenylhydr...
Measurement of a genotoxic hydrazine, agaritine, and its derivatives by HPLC with fluorescence derivatization in the agaricus mushroom and its products.Chem. Pharm. Bull. 54(6) , 922-4, (2006)
Agaricus blazei MURRILL mushroom products are sold as so-called health foods in Japan. However, a part of Agaricus is known to contain hydrazines. A sensitive and specific method for analyzing a genot...