L-2-Hydroxyglutaric acid disodium

Names

[ Name ]:
L-2-Hydroxyglutaric acid disodium

[Synonym ]:
Pentanedioic acid, 2-hydroxy-, sodium salt (1:2)
(2S)-2-Hydroxyglutaric Acid Disodium Salt
Disodium 2-hydroxypentanedioate

Biological Activity

[Description]:

L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Demethylase

[In Vitro]

L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].

[References]

[1]. Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8.

[2]. da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24.

Chemical & Physical Properties

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C₅H₆Na₂O₅

[ Molecular Weight ]:
192.078

[ Exact Mass ]:
192.001068

[ PSA ]:
100.49000

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues.

Anal. Biochem. 459 , 1-11, (2014)

Hypoxia-inducible factor-1 alpha (HIF-1α) is an important marker of hypoxia in human tumors and has been implicated in tumor progression. Drugs targeting HIF-1α are being developed, but the ability to...

Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China.

Proc. Natl. Acad. Sci. U. S. A. 110(42) , 17017-22, (2013)

The 2-hydroxyglutarate (2-HG) has been reported to result from mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes and to function as an "oncometabolite." To evaluate the clinical sign...

Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.

J. Clin. Oncol. 32(4) , 297-305, (2014)

Mutated isocitrate dehydrogenases (IDHs) 1 and 2 produce high levels of 2-hydroxyglutarate (2-HG). We investigated whether, in acute myeloid leukemia (AML), serum 2-HG would predict the presence of ID...