N2-ibu-2'-OMe-rG

Names

[ Name ]:
N2-ibu-2'-OMe-rG

[Synonym ]:
N2-isobutyryl-2'-O-methylguanosine
IBU-2'-OME-G
2'-O-methyl-N2-isobutyrylguanosine
N2-isobutyryl-O2'-methyl-guanosine
N2-ibu-2'-OMe-rG

Biological Activity

[Description]:

N2-Isobutyryl-2'-O-methylguanosine (N2-IBU-2'-OME-RG) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.68±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C₁₅H₂₁N₅O₆

[ Molecular Weight ]:
367.36

[ Exact Mass ]:
367.14900

[ PSA ]:
151.59000

[ Storage condition ]:
2-8℃

N2-ibu-2'-OMe-rG

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds