BC-23

Names

[ Name ]:
BC-23

Biological Activity

[Description]:

BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[References]

[1]. Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92.

[2]. Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407.

Chemical & Physical Properties

[ Density]:
1.56g/cm3

[ Boiling Point ]:
615.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₁₄ClN₃O₄S

[ Molecular Weight ]:
439.87

[ Flash Point ]:
326.3ºC

[ Exact Mass ]:
439.03900

[ PSA ]:
113.61000

[ LogP ]:
5.05070

[ Index of Refraction ]:
1.721

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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